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ea0037oc9.5 | Adrenal 2 | ECE2015

The Notch ligand Jagged1 is up-regulated in adrenocortical carcinomas and is associated with a favourable clinical outcome

Ronchi Cristina , Sbiera Silviu , Altieri Barbara , Steinhauer Sonja , Wild Vanessa , Bekteshi Michaela , Kroiss Matthias , Fassnacht Martin , Allolio Bruno

Background: Adrenocortical tumours consist of frequent adrenocortical adenomas (ACA) and highly malignant (ACC) with a still incompletely understood pathogenesis. Dysregulation of Notch signalling pathway is implicated in several cancers with oncogenic or tumour suppressor functions. Copy number gains and over-expression of Jagged1, a ligand of Notch receptor, was reported in ACC. The aim of the study was to evaluate the expression of Jagged1 and other Notch-r...

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ea0037ep1131 | Endocrine tumours | ECE2015

Inhibitor of apoptosis protein livin/BIRC7 in adrenocortical tumours

Altieri Barbara , Sbiera Silviu , Casa Silvia Della , Steinhauer Sonja , Wild Vanessa , Fadda Guido , Bekteshi Michaela , Rosenwald Andreas , Pontecorvi Alfredo , Fassnacht Martin , Allolio Bruno , Ronchi Cristina L

Introduction: Adrenocortical tumours comprise frequent adenomas (ACA) and rare highly malignant carcinoma (ACC). Livin/ML-IAP/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumorigenesis, mostly through the inhibition of caspase-3. Aim of the study was to evaluate the expression of livin/BIRC7 in normal and neoplastic adrenal glands.Methods: The mRNA expression of BIRC7, its isoforms livin α...

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Endocrine Abstracts

The Notch ligand Jagged1 is up-regulated in adrenocortical carcinomas and is associated with a favourable clinical outcome

Inhibitor of apoptosis protein livin/BIRC7 in adrenocortical tumours

BiosciAbstracts